Effect of Nimbidin on Gastric Acid Secretion
نویسندگان
چکیده
Nimbidin, the crude bitter compound from neem has been investigated for its gastric anti secretory activity in rats and cats. It exhibited significant anti - secretory activity in pylorus ligated rats and cats. In lumen - perfused rats it suppressed the basal as well as histamine and carbachol stimulated gastric acid output at 40 mg/kg (i.v). However it had no effect on ASA - induced back - diffusion of H+ ions. This anti secretory activity of nimbidin was found to be similar to that of H2 - receptor antagonists, which are reported to suppress the histamine induced gastric secretion in animals and man.
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